<i>In Silico</i> analysis and linking of metabolism-related genes with the immune landscape in head and neck squamous cell carcinoma

Metabolic reprogramming and immunologic suppression are two critical characteristics promoting the progression of head and neck squamous cell carcinoma (HNSCC). The integrative analysis of all the metabolism-related genes (MRGs) in HNSCC is lacking and the interaction between the metabolism and the immune characteristics also requires more exploration to uncover the potential mechanisms. Therefore, this study was designed to establish a prognostic signature based on all the MRGs in HNSCC. Genes of HNSCC samples were available from the TCGA and GEO databases while the MRGs were retrieved from a previous study. Ultimately 4 prognostic MRGs were selected to construct a model possessing robust prognostic value and accuracy in TCGA cohorts. The favorable reproducibility of this model was confirmed in validation cohorts from GEO databases. The risk score calculated by this model was an independent prognostic factor that further classified these HNSCC patients into high-/low-risk groups. GSEA analyses and somatic mutations indicated the low-risk group could activate several anti-tumor pathways and possessed lower TP53 mutation. The results of ESTIMATE, single-sample GSEA, CIBERSORT, and some immune-related molecules analyses suggested the low-risk group exhibited lower metabolic activities and higher immune characteristics. The Spearman correlation test implied most metabolic pathways with tumor-promoting function were negatively correlated with the immune activity, indicating a plausible approach of combining the anti-metabolism and the immunotherapy drugs in the high-risk group to enhance therapeutic effects than applied separately. In conclusion, this prognostic signature linking MRGs with the immune landscape could promote the individualized treatment for HNSCC patients.     

新版学科目录“设计”类学科迎来重大结构性调整的几点解读

持续近两年时间的新一轮学科专业目录修订工作即将迎来正式公布，新版学科专业目录将在尊重人才培养规律和学科发展趋势的基础上，遵照稳中求进的总基调，在对“设计学”学术型专业归类调整的同时，稳步推进博士、硕士研究生专业学位类别的增设，以提高学科门类的实践性与综合性的融合度。据此，针对新版学科专业目录“设计”类学科进行解读，从其学科重大结构性调整来看，实现了具有关联性学科的重新归类，以及新兴应用型门类专业点的增设，既配合了“设计”类学科重视基础、拓展前沿的发展趋势，以及创意与技能并举的人才培养新需求，又考虑到我国教育统计的历史分类与未来社会发展领域的需要。相比较来说，“设计”类学科是此次新版学科专业目录中“艺术”类学科调整获益最大的学科。简言之，可以归纳为一个归类、两个增设的调整，即有关原“设计学”一级学科(1305)在新版学科专业目录中分别被调整归类到“艺术学”(1301)之中，延续原学科的历史、理论研究方向；并增设两个“设计”类学科点，一个是专业学位点(1357设计)，含新增专业博士和硕士学位点；另一个是交叉学科的“设计学”学科点(1403)，可授予工学、艺术学位。实事求是说，此次新学科目录的颁布将完善放管结合的学科专业目录运行机制，进一步增强高校学科专业设置自主权，推动学科专业目录向指导性、统计性和应用性转变。     

基于CPET时序聚类的中长跑耐力运动员选拔方法

心肺运动试验（CPET）能将人体的呼吸系统、心血管系统等综合为一体，不仅能够体现受试者的有氧运动能力，评估受试者的心肺耐力，而且能以整体整合医学的视角来研究受试者对运动的应激反应。为对CPET数据进行凝聚层次聚类分析，提出一种基于时间序列形态特征的算法。选取15名业余中长跑运动员的CPET数据作为聚类对象，聚类指标选取了表征有氧能力和心肺耐量的耗氧量、二氧化碳、心率、分钟通气当量、代谢当量、生理死腔与潮气量比值、呼吸商及每搏输出量等8类指标，体现运动员摄取、利用氧的效率、肺循环以及心功能等综合状况。通过聚类分析发现受试者个体差异较大，未出现明显的“群居分布”特征，根据轮廓系数评估可剔除心肺耐量较差的测试者。实验结果表明，该算法在确保聚类准确率的同时能够降低数据压缩率，且对形态特征显著的数据集进行聚类效果更佳。     

液滴撞击液膜过程气泡卷吸的FTM数值模拟

采用界面追踪法(front tracking method,FTM)对液滴撞击液膜形成的气泡卷吸现象进行直接数值模拟,分析不同无量纲液膜厚度(H*)和不同Bo对卷吸气泡出现时间和消失时间的影响。结果表明:在Bo=4.00时,H*的增加会使得卷吸气泡出现和消失的时间提前,并且在H*0.415时,卷吸气泡不再出现;在H*分别为0.250和0.150时,卷吸气泡不再出现的临界Bo分别为3.58和3.19,但不同的H*对卷吸气泡出现和消失的时间的影响与固定Bo时趋势一致。     

Microstructural characteristics of as-forged and β-air-cooled Zr–2.5Nb alloy

Multiple characterization and analysis techniques including electron backscatter diffraction (EBSD), electron channeling contrast (ECC) imaging, transmission electron microscopy (TEM) and microhardness test were jointly employed to investigate microstructural characteristics such as local composition, morphology, grain boundary characteristics and interphase orientation relationship of a forged Zr–2.5Nb alloy before and after β-air-cooling. Results show that the as-forged specimen is composed of equiaxed and lamellar α grains and continuous net-like β-Zr films. After the β-air-cooling, the microstructure of the specimen is featured by basket-weave Widmanstätten structure, in which the inter-α-plate second phases are nanoscale β-Zr. Analyses for crystallographic orientations reveal that the Burgers relationship has been strictly followed during the β→α cooling. Compared to the as-forged specimen, the hardness of the β-air-cooled specimen is higher, which could be attributed to the decreased structural sizes of both α and β phases, and the increased fraction of high angle boundaries as well.     

基于ECMWF和WRF的嘉陵江流域面雨量预报精度评估

将降雨数值预报产品运用到水文预报中已经逐渐成为提高洪水作业预报的预见期的重要手段。为充分了解ECMWF(European Centre for Medium Range Weather Forecasts)和WRF(Weather Research and Forecasting model)2种数值天气预报产品对嘉陵江研究区面雨量预报的预报精度和误差分布,且为增强洪水预报精度的稳健性提供科学支持,采用TS评分、空报率、漏报率、正确率等指标,对嘉陵江地区7个气象分区内的2016年汛期面雨量预报结果进行了检验,分析了不同分区内各检验指标与预报时效的关系。结果表明:ECMWF数值预报产品和WRF数值预报产品均可用于该地区晴雨预报,且2种产品的预报精度随降水等级的增大呈增大趋势,随预报时效的增加呈减小趋势。综合而言,ECMWF数值预报产品对嘉陵江研究区的预报效果更好。     

Isogeometric topology optimization based on energy penalization for symmetric structure

We present an energy penalization method for isogeometric topology optimization using moving morphable components (ITO–MMC), propose an ITO–MMC with an additional bilateral or periodic symmetric constraint for symmetric structures, and then extend the proposed energy penalization method to an ITO–MMC with a symmetric constraint. The energy penalization method can solve the problems of numerical instability and convergence for the ITO–MMC and the ITO–MMC subjected to the structural symmetric constraint with asymmetric loads. Topology optimization problems of asymmetric, bilateral symmetric, and periodic symmetric structures are discussed to validate the effectiveness of the proposed energy penalization approach. Compared with the conventional ITO–MMC, the energy penalization method for the ITO–MMC can improve the convergence rate from 18.6% to 44.5% for the optimization of the asymmetric structure. For the ITO–MMC under a bilateral symmetric constraint, the proposed method can reduce the objective value by 5.6% and obtain a final optimized topology that has a clear boundary with decreased iterations. For the ITO–MMC under a periodic symmetric constraint, the proposed energy penalization method can dramatically reduce the number of iterations and obtain a speedup of more than 2.     

小庄煤矿液态CO2防灭火技术实践

针对小庄煤矿40203综放工作面采空区出现自然发火隐患问题,分析了该工作面自然发火原因、液态CO 2防灭火机理及施工工艺,成功实施了液态CO 2防灭火技术在现场的应用。在向40203综放工作面采空区灌注液态CO 2后,采空区出水温度由灌注前的36℃降至26.5℃,上隅角袋子墙内CO浓度由灌注前的0.0067%降至0.0051%,上隅角采空区19 m处CO浓度由灌注前的0.0072%降至0.0053%,采空区出水温度和CO浓度显著下降并维持稳定。实践表明,该技术成功遏制了采空区遗煤进一步氧化升温,消除了采空区自然发火隐患,保证了工作面的安全回采,也为矿井防灭火工作积累了可借鉴的实践经验。     

通用型液压马达实验台的分析与设计

通用型液压马达实验台的检测实验装置能够模拟实际工况对不同类型、多种规格的液压马达进行性能测试。设计一种通用型液压马达,包括实验台的连接支架设计、转速扭矩仪选型、负载系统设计、油箱设计及油路优化,并对设计参数进行了计算与有限元验证。该实验台可按照国家标准和检测方法,对多种类型不同型号液压马达做性能测试。